The Black Eyed Peas have already performed on the bus and now young musicians from Dublin will get the chance.
The bus, unveiled by Yoko Ono in Liverpool last May is traveling around Europe and the US offering kids the chance to develop their musical talents.
The bus has three on-board engineers, young aspiring musicians learn how to write, perform, record, and produce original songs, as well as produce and shoot music videos.
It has been stationed in Knocknaheeny in Cork for the past week where it has tutored kids involved in 'Music Generation', the U2-funded music education programme.
Music Generation say people should come and check out the bus because "it's probably the only time it will be in Ireland."
The bus pulls up in Essex Street East on Thursday morning for a public open day. "The public open day is a chance for everyone to get on and see the bus. It's a state-of-the-art music studio inside. The whole thing is more akin to a gigantic truck than a bus," says Murphy.
Lord Mayor of Dublin Oisin Quinn visits the bus at 11.30am today.