The HSE has issued a warning ahead of the summer festival season about a surge in high-risk substances now circulating in Ireland, including new "ketamine analogues" and "high-strength MDMA pills."

“You can’t tell what’s in a powder just by looking at it, and even a small amount could have serious health effects,” read the statement from the HSE.

According to the HSE, these substances, especially when mixed with other drugs or alcohol, significantly increase the risk of overdose or mental health emergencies. The statement also cited growing concerns about how ketamine use may impact bladder and mental health long-term.

Also known as designer drugs, these new types of ketamine are designed to mimic its effects but may cause far more intense and unpredictable reactions.

The HSE also said that MDMA pills and powders have become far more potent. HSE data from 2024 shows that 1 in 4 ecstasy pills tested contained more than 200 mg of MDMA, over twice the typical adult dose.

"One pill doesn’t necessarily equal one dose," said the HSE. "We’re also seeing more people mixing MDMA powder in drinks, which has led to emergencies at events."

Professor Eamon Keenan, the HSE’s National Clinical Lead for Addiction Services, urged festival-goers to "look at our information and stay informed on the current drug market."

"It is a concerning time as risks are increasing as a result of drug market changes, with new drugs starting to appear across European markets which can have unpredictable effects."

The HSE urges anyone planning to attend festivals to stay with friends, avoid mixing substances and seek on-site medical help if needed.