Full House actor and beloved comedian Bob Saget has died suddenly aged 65, his family has announced.

Saget was pronounced dead at the Ritz-Carlton Hotel in Orlando, Florida on Sunday after staff found him unresponsive in his room. The cause of death remains unclear but the Orange County’s Sheriff’s Department said initial enquiries showed no signs of foul play or drug use.

"We are devastated to confirm that our beloved Bob passed away today," his family said in a statement.

"He was everything to us and we want you to know how much he loved his fans, performing live and bringing people from all walks of life together with laughter."

The comedian had just recently embarked on his 2022 stand-up tour and posted a tweet about his Jacksonville show where he declared his delight to be back performing.

“Loved tonight’s show @PV_ConcertHall in Jacksonville. Appreciative audience. Thanks again to @RealTimWilkins for opening. I had no idea I did a 2 hr set tonight. I’m happily addicted again to this shit,” he wrote.

Loved tonight’s show @PV_ConcertHall in Jacksonville. Appreciative audience. Thanks again to @RealTimWilkins for opening. I had no idea I did a 2 hr set tonight. I’m happily addicted again to this shit. Check https://t.co/nqJyTiiezU for my dates in 2022. pic.twitter.com/pEgFuXxLd3

— bob saget (@bobsaget) January 9, 2022

Tributes have flooded in for the legendary actor and comedian:

"Sail on my friend Bob Saget with your huge heart and abject lunacy,” wrote American TV host Whoopi Goldberg. “My condolences to his daughters & other family,” she added.

Sail on my friend Bob Saget With your huge heart and abject lunacy,my condolences to his daughters & other family

— Whoopi Goldberg (@WhoopiGoldberg) January 10, 2022

John Stamos, who starred as Uncle Jesse alongside Saget in Full House, also expressed his grief at his friend’s death:

“I am broken. I am gutted. I am in complete and utter shock. I will never ever have another friend like him. I love you so much Bobby,” he said.

I am broken. I am gutted. I am in complete and utter shock. I will never ever have another friend like him. I love you so much Bobby.

— John Stamos (@JohnStamos) January 10, 2022

"Damn it @bobsaget you left your body. I'll forever celebrate your genius, your giant heart, and joy for life. Thank you for helping me through the inevitable sadness of life with comedy. At least now you can hang with Rodney & Don again. Love you forever,” wrote actor Seth Green.

Star Trek actor George Takei referred to Saget as “America’s Dad” in a touching tribute to the late star.

"Deeply saddened to learn of the untimely passing of comedian Bob Saget," he said. "Beloved by millions as America’s Dad, he was a regular presence in our living rooms, bringing to us the funniest videos and countless belly laughs.”

"Gone too soon, like so many of the brightest souls", he added.

"In terrible shock of the horrible news of Bob Saget’s sudden passing," British comedian and Great British Bake Off Matt Lucas said on Twitter.

"He was a warm, kind, humble man and a magnificently naughty comedian, always treading the line so deftly. He will be greatly missed."

Comedic royalty and pop culture icon Jim Carrey also lent his tender words in a tribute to the actor who played the role of Danny Tanner on Full House.

"Beautiful Bob Saget passed away today at 65. He had a big, big heart and a wonderfully warped comic mind. He gave the world a lot of joy and lived his life for goodness' sake”, he wrote.

Beautiful Bob Saget passed away today at 65. He had a big, big heart and a wonderfully warped comic mind. He gave the world a lot of joy and lived his life for goodness’ sake. :’^} pic.twitter.com/QVSITsfaVj

— Jim Carrey (@JimCarrey) January 10, 2022