65-year-old Reggie Lucas died in a New York hospital on Saturday. He died from complications with his heart, according to his daughter.
Lucas, who produced most tracks on Madonna's debut album back in 1983, was also a musician himself, having played with Miles Davies back in the 1970s.
He also co-wrote several hits singles with James Mtume for artists such as Roberta Flack and Donny Hathaway.
"After a long and arduous struggle with his physical heart (his emotional one was perfect) he was called home," Reggie's daughter, Lisa wrote on Facebook.
"I wish he'd had more time, I wish we'd all had more time with him, but he left this world absolutely covered in love, with his hands held and his family beside him.
"I'm glad he's at peace now."
In her touching Twitter post, Madonna said she was "so sad to hear that Reggie Lucas is gone".

So Sad to hear that Reggie Lucas is Gone.........An important part of my musical past! ?♥️?♥️?♥️ RIP ?? #gratitude #luckystar ⭐️ pic.twitter.com/tNUbzgTwRe

— Madonna (@Madonna) May 20, 2018