Tickets for the February 22 performance go on sale tomorrow (Thursday, November 23) at 9 am.
The Dublin show marks Hughes's return to his career beginnings in stand-up comedy.
In 1990 he became the youngest winner of The Perrier Award. He has also done two series of Sean's Show for Channel 4 as well as starred as captain in the BBC2 music quiz show Never Mind The Buzzcocks.