She will also perform at the Odyssey in Belfast on October 25.
Spears will perform 21 of her biggest hits including two surprise songs.
“I can’t wait to come back to Ireland and the UK and perform for my fans there, it’s been to long,” she enthuses.
Femme Fatale debuted at No. 1 in the US Billboard 200 and No. 4 in the Irish album charts. The critically acclaimed album which includes hits like ‘Till The World Ends’ and ‘Hold It Against Me’, will see third single ‘I Wanna Go’ released on August 8.
Tickets for the O2 gig are on sale at Ticketmaster from €54.80.