Cillian Murphy, the Cork-born actor whose CV includes Batman Begins and A Girl With A Pearl Earring, is up for a gong for his role as a young Irish transvestite in Breakfast On Pluto.
But also in the snappily-named Actor In A Leading Role - Musical Or Comedy category is fellow Irishman Pierce Brosnan, who is given a nod for playing an assassin in The Matador.
The awards take place on January 16, with other nominees including Russell Crowe, Heath Ledger, Charlize Theron and Sarah Jessica Parker.
Click for a full list of nominations.